Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen
نویسندگان
چکیده
منابع مشابه
Interleukin-7 Worsens Graft-vs-Host Disease
(1844 articles) Transplantation (4939 articles) Immunobiology Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Infor...
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Graft-vs.-host (GVH)-related immunosuppression has previously been demonstrated in F1 rodent recipients of parental lymphoid cells, and has been thought to result from an immunologic attack of the donor against the host. Since all cells of such F1 recipients could potentially bear target class I MHC alloantigens, it has not previously been possible to determine precisely the target tissues resp...
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Spleen cells from BALB/c and C57BL/6 mice were tested for their reactivity against reciprocal hybrid tissues ((BALB/c x C57BL/6) F(1) and (C57BL/6 x BALB/c) F(1)) in three assay systems: the mixed lymphocyte reaction (MLR); the Simonsen spleen-weight graft-vs.-host (GVH) assay; and a GVH mortality assay. It was shown that both F(1)'s serve as equally effective stimulators of parental cells in t...
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The primary purpose of this study has been to validate the in vitro graft-vs.-host reaction as an experimental system. Time-dose studies have been presented for cells obtained from spleen, thymus, cortisone-treated thymus, inguinal lymph node, mesenteric lymph node, thoracic duct, and bone marrow cells. Both the degree of splenomegaly and the onset of spleen enlargement were found to be depende...
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tributed equally to this study. Study concept and design: C. Lim and S.-L. Lim. Acquisition of data: C. Lim and S.-L. Lim. Analysis and interpretation of data: C. Lim and S.-L. Lim. Drafting of the manuscript: C. Lim and S.-L. Lim. Critical revision of the manuscript for important intellectual content: C. Lim and S.-L. Lim. Administrative, technical, and material support: C. Lim and S.-L. Lim. ...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 1999
ISSN: 1083-8791
DOI: 10.1053/bbmt.1999.v5.pm10392959