Lymphocyte traffic and homing in autoimmune thyroid disorders

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منابع مشابه

Lymphocyte traffic and homing in autoimmune thyroid disorders.

Human autoimmune thyroid disorders (AITD) – Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) – are characterized by reactivity to self thyroid antigens, which may be expressed as destructive inflammatory or anti-receptor autoimmune diseases (1–3). In AITD, the autoimmune process is probably initiated by the activation of autoreactive T cells by an MHC II/self antigen complex and a co-stimu...

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Autoimmune Thyroid Disorders

Thyroid autoimmunity, as reflected by the presence in serum of autoantibodies directed against the thyroid autoantigens thyroglobulin (Tg) and thyroid peroxidase (TPO), is present in >10% of the US population over 12 years of age [1] and is the most common cause of endocrine dysfunction in iodine-sufficient populations [2]. The underlying mechanism is a failure of T-cell tolerance leading to ly...

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Autoimmune Thyroid Disorders

Purpose of Review. Studies have been published in the field of autoimmune thyroid diseases since January 2005. The review is organized into areas of etiology, autoimmune features, autoantibodies, mechanism of thyroid cell injury, B-cell responses, and T-cell responses. Also it reviews the diagnosis and the relationship between autoimmune thyroid disease, neoplasm, and kidney disorders. Recent F...

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Vitiligo and Autoimmune Thyroid Disorders

Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected by vitiligo usually show a poorer quality of life and are more likely to suff...

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Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders

CONTEXT There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders...

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ژورنال

عنوان ژورنال: European Journal of Endocrinology

سال: 1999

ISSN: 0804-4643,1479-683X

DOI: 10.1530/eje.0.1400287