LYMPHOCYTE SIGNALLING: Adapting B-cell responses
نویسندگان
چکیده
منابع مشابه
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Grb2 is a ubiquitously expressed adaptor protein, which activates Ras and MAP kinases in growth factor receptor signalling, while in B-cell receptor (BCR) signalling this role is controversial. In B cell lines it was shown that Grb2 can inhibit BCR-induced Ca(2+) signalling. Nonetheless, the physiological role of Grb2 in primary B cells is still unknown. We generated a B-cell-specific Grb2-defi...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2002
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri787