Lymphocyte sensitivity to human skeletal muscle antigen in polymyositis.

Lymphocyte stimulation with muscle homogenate in polymyositis and other muscle-wasting disorders.

Polymyositis is a non-hereditary disorder chiefly affecting the musculature of the limb girdles, neck, and pharynx (Walton and Adams, 1959; Barwick and Walton, 1963); it has features suggesting an immunological pathogenesis-notably the histology, the association with collagen disorders and malignancy, and the responsiveness to steroids and immunosuppressive agents (Walton and Adams, 1959; Barwi...

Frequency of Bovine Lymphocyte Antigen DRB3.2 Alleles in Sarabi Cows

Abnormalities of lymphocyte subsets in polymyositis.

bilateral pulmonary nodules. Histological examination of a biopsy sample of the thigh mass suggested synovial sarcoma. Because of the metastatic pulmonary lesions 150 mg doxorubicin was given by intravenous injection. Three days later the haemoglobin concentration fell suddenly to 10-6 g/dl (reticulocytes 4-1%'). Results of Coombs tests were negative. Supravital staining (cresyl blue) of a bloo...

Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle.

The present study examined the sensitivity of carnitine palmitoyltransferase I (CPT I) activity to its inhibitor malonyl-CoA (M-CoA), and simulated metabolic conditions of rest and exercise, in aerobically trained and untrained humans. Maximal CPT I activity was measured in mitochondria isolated from resting human skeletal muscle. Mean CPT I activity was 492.8 +/- 72.8 and 260.8 +/- 33.6 microm...

Sensitivity of skeletal muscle to pro-apoptotic factors.

In mononuclear cells, apoptosis leads to DNA fragmentation and cell destruction, regardless of the activated pathway. As regards multinuclear cells, e.g. skeletal muscle fibers, apoptosis rarely induces the death of the entire cell, and it generally affects single nuclei. This process, referred to as nuclear apoptosis, has a negative effect on the expression of genes in the myonuclear domain. A...