Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis
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چکیده
منابع مشابه
Serum 25-hydroxyvitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis.
BACKGROUND Vitamin D exerts anti-inflammatory actions both in vitro and in murine models of colitis. In previous studies, we demonstrated that vitamin D protects against the development of colitis by maintaining the integrity of the intestinal mucosal barrier. OBJECTIVE We sought to evaluate whether deficient serum 25 hydroxyvitamin D [25(OH)D] concentrations are associated with increased muc...
متن کاملLag - 3 , a Novel Lymphocyte Activation Gene
A number of cell surface structures are thought to belong to the Ig superfamily (IgSF) t because they contain at least one domain with a characteristic folding pattern, called the Ig fold (reviewed in reference 1) . Several of these molecules have critical functions in immune responses . In addition to ensuring specific antigen recognition (Ig, TCR), they may function as monomorphic ligands cri...
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Background : Ulcerative colitis an inflammatory bowel disease (IBD) and chronically idiopathic immune related that associates with extraintestinal manifestations such as arthritis. Despite of the highly specificity ofanti-cyclic citrullinated peptide (CCP) antibodies for rheumatoid arthritis, their role in IBD remains unclear . There are only a few studies on the prevalence of anti-CCP antibo...
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BACKGROUND The goals of treating ulcerative colitis (UC) have shifted from clinical remission to mucosal healing. Non-invasive biomarkers are required to assess mucosal healing as endoscopic assessment is inconvenient for patients. Enhanced expression of trefoil factor 3 (TFF3, a mucin-associated peptide) is observed after injury of the gastrointestinal tract. The present study was designed to ...
متن کاملInterleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis.
BACKGROUND AND AIM Approximately one third of patients with acute severe ulcerative colitis (ASC) will fail intravenous corticosteroids (IVCS). Predicting response to IVCS to initiate early salvage therapy remains challenging. The aim of this study was to evaluate the role of serum inflammatory cytokines in ASC and determine their predictive utility with IVCS treatment failure. METHODS This p...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2020
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjaa054