LXXV.—A study of the substitution products of ar-tetrahydro-α-naphthylamine. 4-Bromotetrahydro-α-naphthylamine and ar-tetrahydro-α-naphthylamine-4-sulphonic acid
نویسندگان
چکیده
منابع مشابه
Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC(50) < 10 μg/mL) again...
متن کاملSertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.
Sertraline [1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine] was found to be a highly selective and potent competitive inhibitor of synaptosomal serotonin uptake. Sertraline also selectively reduced ex vivo uptake of serotonin and strongly antagonized the serotonin-depleting action of p-chloroamphetamine, indicating potent blockade of serotonin uptake in vivo. Acute and...
متن کاملThe practical synthesis of (2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine via optical resolution of 2-(3-methoxybenzyl)succinic acid.
We describe the practical synthetic route for (2S)-7-methoxy-1,2,3,4-tetrahydro-2-naphthylamine 1(2S)-2-amino-7-methoxytetraline; (S)-AMT]. (2R)-2-(3-Methoxybenzyl)succinic acid [(R)-1] was obtained by the optical resolution of 2-(3-methoxybenzyl)succinic acid (1) as the salt of (1R,2S)-2-(benzylamino)cyclohexylmethanol (7), and (R)-1 was converted to the optically active (2S)-7-methoxy-1,2,3,4...
متن کاملEfficient Synthesis and Characterization Of 4-Thiazolidinone derivatives by 3-Formylindole and 2-Naphthylamine
A series of 4-Thiazolidinone derivatives were synthesized by reaction of 3-formyl-2-arylindole derivatives, 2aminonaphthaline and mercaptoacetic acid. The structures of the new compounds were assigned on the basis of their analytical and spectral data.
متن کاملCarcinogenicity testing of N-hydroxy and other oxidation and decomposition products of 1- and 2-naphthylamine.
Af-Hydroxy-2-naphthylamine produced bladder tumors in three of four dogs when administered over a period of 30 months (dogs were sacrificed 15 months later) in dimethyl sulfoxide solution by repeated instillation directly into the bladders. ./V-Hydroxy-1-naphthylamine was more carcinogenic than TV-hydroxy^-naphthylamine by administration to rats, but the reverse was observed in four experiments...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: J. Chem. Soc., Trans.
سال: 1904
ISSN: 0368-1645
DOI: 10.1039/ct9048500736