Lupus nephritis in the new millennium

The prognosis of lupus nephritis in children

Introduction: Lupus nephritis is a systemic disease which affects different organs. The present study was designed to review lupus nephritis, in children its outcome and the related factors. Methods: We reviewed 48 children with lupus nephritis. Clinical and epidemiological features were studied. The patients’ outcomes and related factors were analyzed. Patient and renal survival rate were ca...

The evidence base for the treatment of lupus nephritis in the new millennium.

New therapies for lupus nephritis.

R enal involvement is frequent in patients with systemic lupus erythematosus (SLE) and may strongly influence their expectancy and quality of life. Until recently, the treatment of lupus nephritis mainly rested on three drugs: corticosteroids, cyclophosphamide, and azathioprine. However, newer agents have been introduced in the last few years. In this paper, the available treatments for lupus n...

New Therapeutic Strategies in Lupus Nephritis

Complement in Lupus Nephritis: New Perspectives.

BACKGROUND Systemic lupus erythematosus (SLE) is an autoimmune disorder caused by loss of tolerance to self-antigens, the production of autoantibodies and deposition of complement-fixing immune complexes (ICs) in injured tissues. SLE is characterized by a wide range of clinical manifestations and targeted organs, with lupus nephritis being one of the most serious complications. The complement s...