Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury

Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury

Acute lung injury (ALI) is a severe inflammatory process of the lung. The only proven life-saving support is mechanical ventilation (MV) using low tidal volumes (LVT) plus moderate to high levels of positive end-expiratory pressure (PEEP). However, it is currently unknown how they exert the protective effects. To identify the molecular mechanisms modulated by protective MV, this study reports t...

Correction: Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury

The accession number for the complete microarray data set deposited in ArrayExpress appears incorrectly throughout the article as E-MEXP-12345. The correct accession number should be E-MTAB-2673. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author a...

Pressure-targeted, lung-protective ventilatory support in acute lung injury.

Mortality in sepsis versus non-sepsis induced acute lung injury

INTRODUCTION Sepsis-induced acute lung injury (ALI) has been reported to have a higher case fatality rate than other causes of ALI. However, differences in the severity of illness in septic vs. non-septic ALI patients might explain this finding. METHODS 520 patients enrolled in the Improving Care of ALI Patients Study (ICAP) were prospectively characterized as having sepsis or non sepsis-indu...

The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of...