Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations

Drug-Induced Changes in Metabolomics of Plasma, Brain Extracellular Fluid and Cerebrospinal Fluid

Analysis of extracellular RNA in cerebrospinal fluid

We examined the extracellular vesicle (EV) and RNA composition of pooled normal cerebrospinal fluid (CSF) samples and CSF from five major neurological disorders: Alzheimer's disease (AD), Parkinson's disease (PD), low-grade glioma (LGG), glioblastoma multiforme (GBM), and subarachnoid haemorrhage (SAH), representing neurodegenerative disease, cancer, and severe acute brain injury. We evaluated:...

Extracellular-superoxide dismutase in cerebrospinal fluid from infants/children.

endothelial cell (HUVEC) and bovine aertic endothelial cell surface proteoglycans was significantly decreased by the incubation with SNAP andNOR4, poterrt nitric oxide (NO) donors. NO derived from lipopolysaccharide-stiinulated J774 A-1 cells also decreased the binding of EC-SOD to HUVEC, and this decrease was blocked by NG-nitro-L-arginine, a itric oxide synthase inhibiter. Furthermore. the de...

Enterobius vermicularis in Cerebrospinal Fluid

Enterobius vermicularis is a nematod of large intestine in man. Extra intestinal localization of this parasite is rare. A 60 year old man was admitted to the hospital with the clinical manifestation of meningitis. In laboratory examination of cerebrospinal fluid (C.S.F), the appearance was red, Albu-min level was high and the glucose showed normal value. Haematoxylin and Eosin stained slides pr...

Cerebrospinal fluid physiology and cerebrospinal fluid drainage.

To the Editor:—We read with interest the article of Conzen et al. demonstrating a reduction of cardiac troponin I release after coronary artery bypass grafting on the beating heart when sevoflurane was compared to propofol. Most previous studies identified peak postoperative troponin I as the major endpoint. It is not clear from the article of Conzen et al. which was the peak postoperative trop...