Lucien J. Rubinstein: enduring contributions to neuro-oncology

Neuro-oncology: an overview.

The direct, indirect, and treatment-related effects of cancer on the nervous system have received variable attention by neurologists over the past century. The diseases encompassed in the neuro-oncology field and our understanding of them have increased rapidly during the past 30 years. In part, progress has been driven by technological achievements in neuroimaging, in particular, computed tomo...

Reply to Letter Neuro-oncology 611

The debate over how much to push the limits of surgical resection for malignant gliomas is not a recent controversy. The cost-benefit analysis about increasing survival with more resection at the expense of function has existed for decades. In 1928, Walter Dandy at the Johns Hopkins Hospital performed hemispherectomies for patients with glioblastoma (GB) and found that these tumors still recurr...

Imaging in neuro-oncology

Imaging plays several key roles in managing brain tumors, including diagnosis, prognosis, and treatment response assessment. Ongoing challenges remain as new therapies emerge and there are urgent needs to find accurate and clinically feasible methods to noninvasively evaluate brain tumors before and after treatment. This review aims to provide an overview of several advanced imaging modalities ...

Hotspots in Neuro-Oncology

Antibody Phage Display Libraries: Contributions to Oncology

Since the advent of phage display technology, dating back to 1985, antibody libraries displayed on filamentous phage surfaces have been used to identify specific binders for many different purposes, including the recognition of tumors. Phage display represents a high-throughput technique for screening billions of random fusion antibodies against virtually any target on the surface or inside can...