LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting
نویسندگان
چکیده
منابع مشابه
The Cre/loxP system and gene targeting in the kidney.
The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby permitting study of the physiological and pathophysiological impact of a given gene product derived from a particular cell type. In the kidney, the Cre/loxP system has been...
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Sequence-specific binding to genomic-size DNA sequences by artificial agents is of major interest for the development of gene-targeting strategies, gene-diagnostic applications, and biotechnical tools. The binding of one such agent, peptide nucleic acid (PNA), to a randomized human genome has been modeled with statistical mass action calculations. With the length of the PNA probe, the average p...
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ژورنال
عنوان ژورنال: BMC Biology
سال: 2012
ISSN: 1741-7007
DOI: 10.1186/1741-7007-10-96