Low Rho activity in hepatocytes prevents apical from basolateral cargo separation duringtrans‐Golgi network to surface transport
نویسندگان
چکیده
منابع مشابه
Iterative sorting of apical and basolateral cargo in Madin–Darby canine kidney cells
For several decades, the trans-Golgi network (TGN) was considered the most distal stop and hence the ultimate protein-sorting station for distinct apical and basolateral transport carriers that reach their respective surface domains in the direct trafficking pathway. However, recent reports of apical and basolateral cargoes traversing post-Golgi compartments accessible to endocytic ligands befo...
متن کاملGlutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein.
The multidrug resistance protein MRP1 and its isoform MRP2 are involved in ATP-dependent glutathione S-conjugate transport and have similar substrate specificities. MRP2 mediates hepatic organic anion transport into bile. The physiological function of MRP1 in hepatocytes is unknown. Previous results show that MRP1 expression is low in quiescent hepatocytes but increased after SV40 large T antig...
متن کاملA new class of carriers that transport selective cargo from the trans Golgi network to the cell surface.
We have isolated a membrane fraction enriched in a class of transport carriers that form at the trans Golgi network (TGN) and are destined for the cell surface in HeLa cells. Protein kinase D (PKD) is required for the biogenesis of these carriers that contain myosin II, Rab6a, Rab8a, and synaptotagmin II, as well as a number of secretory and plasma membrane-specific cargoes. Our findings reveal...
متن کاملContribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.
Previous studies in intact lung suggest that CFTR may play a role in cAMP-regulated fluid transport from the distal air spaces of the lung. However, the potential contribution of different epithelial cells (alveolar epithelial type I, type II, or bronchial epithelial cells) to CFTR-regulated fluid transport is unknown. In this study we determined whether the CFTR gene is expressed in human lung...
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ژورنال
عنوان ژورنال: Traffic
سال: 2020
ISSN: 1398-9219,1600-0854
DOI: 10.1111/tra.12725