Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response

The interaction of microbubbles with high intensity pulsed ultrasound

High intensity pulsed ultrasound when interacting with microbubble contrast agents is potentially useful for biomedical applications such as drug delivery, cancer treatment and tissue ablation. To establish a fundamental understanding of the interaction between a microbubble with a sound wave, numerical simulations are performed using the Boundary Element Method (BEM). Bubble dynamics in terms ...

Interaction of microbubbles with high intensity pulsed ultrasound.

High intensity pulsed ultrasound, interacting with microbubble contrast agents, is potentially useful for drug delivery, cancer treatment, and tissue ablation, among other applications. To establish the fundamental understanding on the interaction of a microbubble (in an infinite volume of water) with an ultrasound pressure field, a numerical study is performed using the boundary element method...

Ultrasound Imaging using the Low-Frequency Response of Microbubbles

When microbubbles are excited by two frequency signals, a nonlinear response signal may occur at the difference frequency. As these two frequencies are made close, this nonlinear response will reside at lowfrequency region. We have derived a theory for the weak short-pulse response based on a two-frequency approximation, which provides the pressure and the bandwidth dependence properties of the...

Enhancement of Focused Ultrasound Treatment by Acoustically Generated Microbubbles

Ultrasound with microbubbles

Conventional ultrasound has well known short comings in the detection and characterisation of focal liver lesions. A false negative rate of up to 30% has been quoted in the detection of liver metastases and its accuracy in the characterisation of focal liver lesions is poor compared to computed tomography (CT) and magnetic resonance (MR). Ultrasound microbubble contrast agents have redressed th...