Low-Intensity Pulsed Ultrasound Prompts Both Functional and Histologic Improvements While Upregulating the Brain-Derived Neurotrophic Factor Expression after Sciatic Crush Injury in Rats

The aim of this study was to determine that low-intensity pulsed ultrasound (LIPUS) at an intensity 140 mW/cm2 promotes functional and histologic improvements in sciatic nerve crush injury a rat model investigate changes over time relevant growth factors receptors, exploring the mechanism LIPUS recovery process after injury. Toe angle toe-off phase, regenerative axonal length, myelinated fiber density, diameter fiber, axon myelin sheath thickness were significantly higher group than sham group. Gene protein expression brain-derived neurotrophic factor (BDNF) upregulated In conclusion, contributed rapid improvement BDNF rats.