Low-dose Indonesian Aloe vera Increases Viability and Migration of the Fibroblast: An In Vitro Study

BACKGROUND: Important stages in wound healing involve homeostasis, inflammation, proliferation, and remodeling phases. Fibroblasts are essential factors the pathway through process of cell proliferation migration. Aloe vera contains various active compounds used for anti-inflammatory, antimicrobial, immunomodulatory, anticancer, healing. AIM: This study aimed to evaluate effect A. on viability migration fibroblast cells. MATERIALS AND METHODS: were cultured a monolayer with Dulbecco’s Modified Eagle Medium containing 10% fetal bovine serum, 1% pinstripe, 0.5% fungizone. We use fresh leaves extracted 95% ethanol. Cell will be evaluated using MTT test microscopic evaluation. was tested an vitro scratch assay analyzed ImageJ software. RESULTS: stimulated compared control (p < 0.05). Administration does not change shape is toxic fibroblasts. at doses 250, 125, 50, 5 μg/mL after 24 h intervention. At 48 incubation, higher than CONCLUSIONS: extract may effectively by increasing