Low dose, high dose, or no dose: better prescribing of cholinesterase inhibitors for Alzheimer's disease

Low dose, high dose, or no dose: better prescribing of cholinesterase inhibitors for Alzheimer's disease.

Heparin for coronary angioplasty: high dose, low dose, or no dose?

Lactic acidosis: high-dose or low-dose bicarbonate therapy?

occurs intracellularly, extracellularly, and in the cerebrospinal fluid (CSF). Adding sodium bicarbonate to the extracellular fluid causes a decrease in hydrogen ions with subsequent increase in carbon dioxide (CO2) concentration. Since CO2) but not bicarbonate, readily diffuses across cell membranes and into the CSF, this leads to an increase in intracellular and CSF CO2 concentration, with co...

We can do better than effective dose for estimating or comparing low-dose radiation risks.

The effective dose concept was designed to compare the generic risks of exposure to different radiation fields. More commonly these days, it is used to estimate or compare radiation-induced cancer risks. For various reasons, effective dose represents flawed science: for instance, the tissue-specific weighting factors used to calculate effective dose are a subjective mix of different endpoints; ...

Changes in salivary gland function following radioiodine therapy of thyroid diseases: A comparison of high-dose therapy for thyroid cancer and low-dose therapy for benign thyroid disease

Introduction: High-dose radioactive iodine therapy in differentiated thyroid cancer (DTC) may adversely affect the salivary gland function. This study is aimed to evaluate the effect of radioactive iodine (RAI) with dose of 100 mCi in DTC patients compared to lower doses of less than 30 mCi in hyperthyroid cases. Methods: Fifty four patients (13 men and 41 women) age: 42.3±14.3 (21-71) years w...