Longitudinal pharmacokinetic study of .BETA.-carotene.
نویسندگان
چکیده
منابع مشابه
Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study.
Findings from several beta-carotene supplementation trials were unexpected and conflicted with most observational studies. Carotenoids other than beta-carotene are found in a variety of fruits and vegetables and may play a role in this important malignancy, but previous findings regarding the five major carotenoids are inconsistent. The authors analyzed the associations between dietary beta-car...
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We measured carotene in the livers of two patients receiving beta-carotene therapy for photosensitivity. In both patients, the amount of carotene was within reported ranges for patients on normal diets; no abnormal amounts of beta-carotene had accumulated in the livers after oral administration of large amounts of beta-carotene. Light-microscopic examination of the liver (specimen obtained at c...
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Does beta-carotene increase, rather than decrease, human lung cancer rates? A large body of observational epidemiologic study has demonstrated that individuals who eat more fruits and vegetables rich in carotenoids and/or who have higher levels of serum betacarotene have a lower risk of cancer, particularly lung cancer. This inverse relationship has been particularly strong in lung cancer patie...
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The three beta-carotene intervention trials: the Beta Carotene and Retinol Efficacy Trial (CARET), Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), and Physician's Health Study (PHS) have all pointed to a lack of effect of synthetic beta-carotene in decreasing cardiovascular disease or cancer risk in well-nourished populations. The potential contribution of beta-carotene suppleme...
متن کاملBeta-carotene accumulation in serum and skin13
The accumulation off3-carotene in serum and skin was evaluated in human volunteers. A single S I -mg dose of 3-carotene given in the absence of dietary fat resulted in no detectable change in serum /3-carotene. The same dose administered with 200 g fat increased serum /3-carotene 2.5-fold at 40 h. Similarly, administering a-carotene daily in three divided doses with meals raised the serum /3-ca...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1989
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.20.625