Longitudinal Association Analysis of Quantitative Traits
نویسندگان
چکیده
منابع مشابه
Marginal Analysis of A Population-Based Genetic Association Study of Quantitative Traits with Incomplete Longitudinal Data
A common study to investigate gene-environment interaction is designed to be longitudinal and population-based. Data arising from longitudinal association studies often contain missing responses. Naive analysis without taking missingness into account may produce invalid inference, especially when the missing data mechanism depends on the response process. To address this issue in the ana...
متن کاملJoint association analysis of bivariate quantitative and qualitative traits
Univariate genome-wide association analysis of quantitative and qualitative traits has been investigated extensively in the literature. In the presence of correlated phenotypes, it is more intuitive to analyze all phenotypes simultaneously. We describe an efficient likelihood-based approach for the joint association analysis of quantitative and qualitative traits in unrelated individuals. We as...
متن کاملCombined linkage and association sib-pair analysis for quantitative traits.
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a lo...
متن کاملAssociation analysis for quantitative traits by data mining: QHPM.
Previously, we have presented a data mining-based algorithmic approach to genetic association analysis, Haplotype Pattern Mining. We have now extended the approach with the possibility of analysing quantitative traits and utilising covariates. This is accomplished by using a linear model for measuring association. We present results with the extended version, QHPM, with simulated quantitative t...
متن کاملHaplotype-based pharmacogenetic analysis for longitudinal quantitative traits in the presence of dropout.
We propose a variety of methods based on the generalized estimation equations to address the issues encountered in haplotype-based pharmacogenetic analysis, including analysis of longitudinal data with outcome-dependent dropouts, and evaluation of the high-dimensional haplotype and haplotype-drug interaction effects in an overall manner. We use the inverse probability weights to handle the outc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2012
ISSN: 0741-0395
DOI: 10.1002/gepi.21673