Longitudinal assessment of excessive daytime sleepiness in early Parkinson’s disease

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Longitudinal assessment of excessive daytime sleepiness in early Parkinson's disease.

BACKGROUND Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD. METHODS The Parkinson's Progression Markers Initiative is a prospective cohort stu...

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Development of excessive daytime sleepiness in early Parkinson disease.

OBJECTIVE To examine the frequency, development, and risk factors of excessive daytime sleepiness (EDS) in a cohort of originally drug-naive patients with incident Parkinson disease (PD) during the first 5 years after diagnosis. METHODS One hundred fifty-three drug-naive patients with early PD derived from a population-based incident cohort and 169 control participants were assessed for EDS a...

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Assessment and management of excessive daytime sleepiness.

The obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is much the commonest ‘medical’ cause of sleepiness (Table 1), occurring in 1–4% of the middle-aged. OSAHS is the combination of sleepiness or two other major symptoms, such as unrefreshing sleep, difficulty concentrating and nocturnal choking, with five or more apnoeas plus hypopnoeas per hour slept (‘apnoea’ is defined as a 10-sec pause ...

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Excessive daytime sleepiness.

Excessive daytime sleepiness is one of the most common sleep-related patient symptoms, and it affects an estimated 20 percent of the population. Persons with excessive daytime sleepiness are at risk of motor vehicle and work-related incidents, and have poorer health than comparable adults. The most common causes of excessive daytime sleepiness are sleep deprivation, obstructive sleep apnea, and...

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Pharmacotherapy for excessive daytime sleepiness.

Excessive daytime sleepiness (EDS) has recognized detrimental consequences such as road traffic accidents, impaired psychological functioning and reduced work performance. EDS can result from multiple causes such as sleep deprivation, sleep fragmentation, neurological, psychiatric and circadian rhythm disorders. Treating the underlying cause of EDS remains the mainstay of therapy but in those w...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 2017

ISSN: 0022-3050,1468-330X

DOI: 10.1136/jnnp-2016-315023