Long term treatment of chronic Lyme arthritis with benzathine penicillin.

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Long term treatment of chronic Lyme arthritis with benzathine penicillin.

The cases are reported of two patients with chronic Lyme arthritis resistant to the recommended antibiotic regimens who were cured by long term treatment with benzathine penicillin. It is suggested that the sustained therapeutic levels of penicillin were effective either by the inhibition of germ replication or by lysis of the spirochaetes when they were leaving their sanctuaries.

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Neurosyphilis after treatment of latent syphilis with benzathine penicillin.

Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...

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Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin.

The prognosis for 115 rheumatic fever patients subsequently receiving regular intramuscular penicillin prophylaxis for at least 5 years was studied. Average follow-up was 9.3 years, and 57 patients were followed for 10 years or longer. Of the 79 patients with acute mitral regurgitation, 70% lost their murmur from 4 days to 8.5 years after it was first heard. This is in contrast to those with ac...

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Nicolau Syndrome after Intramuscular Benzathine Penicillin Injection

A 3-year-old boy was admitted to the emergency department with right lower limb pain, edema, and livedoid discoloration that occurred immediately after intramuscular injection of benzathine penicillin. The patient was diagnosed with Nicolau syndrome, a rare complication of intramuscular injection presumed to be related to the inadvertent intravascular injection. It was first reported following ...

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Intramuscular versus intravenous administration of benzathine penicillin.

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1992

ISSN: 0003-4967

DOI: 10.1136/ard.51.8.1007