Long-Term Results of TPMT Activity Monitoring in Azathioprine-Treated Renal Allograft Recipients

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Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients.

Thiopurine methyltransferase (TPMT) is implicated in the metabolism of azathioprine. The consequences of differential TPMT activity induction by azathioprine on the long-term results after renal transplantation were investigated. The erythrocyte TPMT activity in 82 patients on days 0, 7, and 30 was prospectively evaluated. Because various patterns of TPMT activity variation were noted, the popu...

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Acute irreversible rejection after withdrawal of azathioprine in renal allograft recipients.

Azathioprine was withdrawn from five recipients after renal transplantation because of hepatic damage. In three out of five cases, clinical courses were uneventful for more than 1 year after withdrawal (Group A). In the other two cases, rejection episodes occurred 3 and 5 months after withdrawal (Group B). Differences in histocompatibility, the interval between the operation and withdrawal, and...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2001

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.v121170