Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: a Cameroonian cohort study (ANRS-12140 Pediacam study, 2008–2013, Cameroon)

Abstract Background In most studies, the virological response is assessed during first two years of antiretroviral treatment initiated in HIV-infected infants. However, early initiation therapy exposes infants to very long-lasting treatment. Moreover, maintaining viral suppression children difficult. We aimed assess virologic and mortality after five (ART) identify factors associated with success Cameroon. Methods ANRS-12140 Pediacam cohort study, 2008–2013, Cameroon, we included all 149 who were still alive ART. Virologic was 5 The probability between ART estimated using Kaplan-Meier curve. immune status also studied at initiation. Factors a load < 400 copies/mL logistic regressions. Results suppressed 66.8% (60.1–73.5) 144 care. Among ART, 64.0% (54.0–74.0). only factor achievement confirmed within (OR = 2.7 (1.1–6.8); p 0.033). Conclusions which quite low highlights difficulty parents administer drugs daily their sub-Saharan Africa. It stressed importance initial for achieving long-term. Further studies should focus on identifying strategies that would enhance better retention care improved adherence Sub-Saharan children.