Long Non-Coding RNAs in Cardiac Hypertrophy

Heart disease represents one of the main challenges in modern medicine with insufficient treatment options. Whole genome sequencing allowed for discovery several classes non-coding RNA (ncRNA) and widened our understanding regulatory circuits. The intrinsic ability long ncRNAs (lncRNAs) circular RNAs (circRNAs) to regulate gene expression by a plethora mechanisms make them candidates conceptually new However, important questions remain be addressed before we can fully exploit therapeutic potential these molecules. Increasing knowledge their action refining approaches modulating lncRNAs are just few face. accurate identification novel is hampered relatively poor cross-species sequence conservation low context-dependent pattern. Nevertheless, progress has been made annotation recent years, while experimental studies have confirmed value as development cardiac hypertrophy other cardiovascular diseases. Here, explore lncRNA biology evidence that this class molecules benefit treat hypertrophy.