Long-lasting protection in brain trauma by endotoxin preconditioning

Ischaemic preconditioning and mitochondrial permeability transition: a long-lasting relationship.

Since its first description 25 years ago, ischaemic preconditioning has become one of the most studied protective interventions in the cardiovascular field, in part due to its universality (it is effective in all animal species tested, including humans, and in different organs) and reproducibility (it has only a weak dependence on the ischaemic protocol applied before sustained ischaemia or on ...

Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance.

OBJECTIVE "Ischemic tolerance" can be induced in the retina by "preconditioning" with brief periods of non-injurious retinal ischemia or systemic hypoxia. The present study was undertaken to assess whether tolerance can be induced pharmacologically by deferroxamine (DFX), an iron chelator, which promotes the expression of the transcription factor, hypoxia-inducible factor 1-alpha (HIF-1alpha), ...

Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism.

Preconditioning the rat brain with spreading depression for 48 h induces potent ischemic tolerance (infarct tolerance) after an interval of 12-15 days, consequently reducing the infarcted lesion size in the acute phase following focal cerebral ischemia. However, persistence of the morphological and functional neuroprotection has not yet been proven. We tested whether tolerance-derived neuroprot...

Vaccine Confers Long-Lasting Protection A Nonadjuvanted Polypeptide Nanoparticle

Glial cells drive preconditioning-induced blood-brain barrier protection.

BACKGROUND AND PURPOSE The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components. METHODS Seven-minute occlusion of the right middle cerebral artery, used as in vivo IPC stimulus 4 days before permanent occlusion of the ...