منابع مشابه
Long-distance splicing.
W ith the draft sequence of the human genome came the surprise that there were fewer genes than imagined. From where does complexity spring if not from the number of genes in an organism? RNA splicing provides at least part of the answer. Pre-mRNA splicing by alternative pathways is well known to expand an organism’s protein diversity by generating distinct protein isoforms. Beyond cis-splicing...
متن کاملPMD patient mutations reveal a long-distance intronic interaction that regulates PLP1/DM20 alternative splicing.
Alternative splicing of the proteolipid protein 1 gene (PLP1) produces two forms, PLP1 and DM20, due to alternative use of 5' splice sites with the same acceptor site in intron 3. The PLP1 form predominates in central nervous system RNA. Mutations that reduce the ratio of PLP1 to DM20, whether mutant or normal protein is formed, result in the X-linked leukodystrophy Pelizaeus-Merzbacher disease...
متن کاملEukaryotic TPP riboswitch regulation of alternative splicing involving long-distance base pairing
Thiamin pyrophosphate (TPP) riboswitches are found in organisms from all three domains of life. Examples in bacteria commonly repress gene expression by terminating transcription or by blocking ribosome binding, whereas most eukaryotic TPP riboswitches are predicted to regulate gene expression by modulating RNA splicing. Given the widespread distribution of eukaryotic TPP riboswitches and the d...
متن کاملDistance Is Dead , Long Live Distance
For many educators, the phrase ‘from distance education to e-learning’ conjures up the view of an ‘evolutionary’ progression beginning with correspondence study and developed through more sophisticated technologies to its current identification with computers, the Internet, and the World Wide Web. For others, particularly those with little knowledge or experience of (and often equally little in...
متن کاملLong distance transport.
A few years ago, I attended a 1-day symposium on long distance transport at a national meeting in a country abroad. Towards the end of the day, as the participants became tired and no general agreement was in sight, one observer from an allied discipline remarked, "Why can't you translocation workers make any progress, you still discuss the same miserable old models that were proposed 40 years ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0803068105