Localization of Preformed, Circulating Immune Complexes in Murine Skin

The Localization of Circulating Immune Complexes in Experimental Serum Sickness

In serum sickness, mechanisms by which circulating immune complexes become localized in the walls of vessels and glomeruli have been studied. In affected arteries, morphologic observations showed that circulating marker particles of carbon would rapidly deposit along the luminal surface of the internal elastic lamina. This, as in previous studies, suggested an increase in vascular permeability ...

Circulating Immune Complexes

A B S TRAC T The presence of circulating immune complexes in freshly drawn sera of patients with various forms of malignancies was detected by the 125I-Clq deviation test of Sobel et al. More than 50% of the 459 cancer sera showed a high inhibition of 125I-Clq uptake by sensitized sheep erythrocytes when compared with sera of50 healthy laboratory personnel. The levels were compared with levels ...

Circulating Immune Complexes

Circulating immune complexes in amoebiasis

Isolated circulating immune complexes (CICs) from sera of patients with amoebiasis were characterized to determine Entamoeba histolytica antigens that participate in the disease process. In total, 116 serum samples were collected before starting anti-amoebic therapy, and their CICs were isolated by differential polyethylene glycol precipitation. The presence of amoeba-specific antigens in CICs ...

Detection of Circulating Immune Complexes

The presumed importance of circulating immune complexes (CIC) in the pathogenesis of glomerulonephritis in man is based on comparisons with animal models (Wilson and Dixon, 1976). There is much indirect evidence suggesting the activity of immune complexes in human glomerulonephritis from (i) demonstration of granular deposits of immunoglobulins and complement components in renal biopsy sections...