Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration
نویسندگان
چکیده
منابع مشابه
CDR2L Antibodies: A New Player in Paraneoplastic Cerebellar Degeneration
OBJECTIVE Yo antibodies are associated with paraneoplastic cerebellar degeneration (PCD). We have characterized Yo sera by measuring CDR2 and CDR2L antibodies and the localization of their antigens. METHODS Forty-two Yo sera from patients with paraneoplastic neurological syndromes (PNS), 179 sera from ovarian and 114 sera from breast cancer patients without PNS and 100 blood donors were scree...
متن کامل[Paraneoplastic cerebellar degeneration].
Paraneoplastic cerebellar degeneration (PCD) is a rare manifestation of cancer, characterized clinically by subacute progressive ataxia, dysarthria and nystagmus. The pathological hallmark of PCD is a severe, diffuse loss of Purkinje cells. PCD occurs most frequently in association with small cell carcinoma of the lung and adenocarcinoma of the ovary, but it has also developed in patients with ...
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Anti-Hu antibody was first discovered in patients with paraneoplastic encephalomyelitis associated with small cell lung cancer (SCLC). This antibody recognises proteins comprised in the Hu family expressed by neuronal cells as well as SCLC. After the first report, anti-Hu antibody was found in other neoplasms including prostate and breast cancer, adrenal carcinoma, chondromyxosarcoma, neuroblas...
متن کاملParaneoplastic cerebellar degeneration and anti-Yo antibodies.
a Servicio de Neurología, Hospital Universitario La Fe, Valencia, Spain b Laboratorio de Neurología Experimental, Centro de Investigación, Hospital Universitario La Fe; Valencia, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) c Servicio de Neurología, Hospital Santa Maria del Rosell, Cartagena, Murcia, Spain d Servicio de Anatomía Patológica,...
متن کاملClinical insights into paraneoplastic cerebellar degeneration.
Neuroimaging is usually unremarkable in paraneoplastic cerebellar degeneration (PCD), at least in the early stages of the disease. A patient with proven PCD is reported in whom it could be shown that cerebellar atrophy evolved very rapidly and was present in early imaging studies. Even with the use of the whole spectrum of modern diagnostic tools, the underlying malignancy can be difficult to d...
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2020
ISSN: 2328-9503,2328-9503
DOI: 10.1002/acn3.51212