منابع مشابه
Modified Cyclodextrins as Novel Non-Viral Vectors for Neuronal siRNA Delivery: Focus on Huntington’s Disease
Modified cyclodextrins as novel non-viral vectors for neuronal siRNA delivery: focus on Huntington’s disease Author(s) Godinho, Bruno M. D. C. Publication date 2014 Original citation Godinho, B. M. D. C. 2014. Modified cyclodextrins as novel non-viral vectors for neuronal siRNA delivery: focus on Huntington’s disease. PhD Thesis, University College Cork. Type of publication Doctoral thesis Righ...
متن کاملNon-viral siRNA delivery into the mouse retina in vivo
BACKGROUND Gene silencing in the retina using RNA interference could open broad possibilities for functional studies of genes in vivo and for therapeutic interventions in eye disorders. Therefore, there is a considerable demand for protocols to deliver siRNA into the vertebrate retina. In this work we explored a possibility to deliver synthetic 21 bp siRNA into the mouse retina after intravitre...
متن کاملNanomaterials as Non-viral siRNA Delivery Agents for Cancer Therapy.
Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-based safe and effective delivery methods are developed. Generally, genes are wrapped up in extremely tiny nanoparticles which could be taken up easily by cancer cells, not to their healthy neighboring cells. Several nanoparticle systems have been investigated primarily to address the problems involv...
متن کاملBiodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing
Degradation of mRNA by RNA interference is one of the most powerful and specific mechanisms for gene silencing. However, insufficient cellular uptake and poor stability have limited its usefulness. Here, we report efficient delivery of siRNA via the use of biodegradable nanoparticles (NPs) made from monomethoxypoly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly-l-lysine (mPEG-PLGA-PLL) tri...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery Science and Technology
سال: 2012
ISSN: 1773-2247
DOI: 10.1016/s1773-2247(12)50002-x