Local Cerebral Blood Flow during Hibernation, a Model of Natural Tolerance to “Cerebral Ischemia”

Coupling of local cerebral blood flow to local cerebral glucose utilization during isoflurane and sevoflurane anesthesia.

Regional cerebral blood flow during hypoxia-ischemia in immature rats.

Immature rats subjected to a combination of unilateral common carotid artery ligation and hypoxia sustain brain damage confined largely to the ipsilateral cerebral hemisphere. To ascertain the extent and distribution of ischemic alterations in the brains of these small animals, we modified the Sakurada technique to measure regional cerebral blood flow using carbon-14 autoradiography. Seven-day-...

Cerebral Blood Flow in Focal Ischemia

A comparison of regional cerebral blood flow measurements made with betaand gamma-emitting isotopes revealed good correspondence in areas of normal perfusion and reactive hyperemia but poor correspondence in areas of focal ischemia. After middle cerebral artery occlusion at normocapnia, there was a 65% reduction in regional cerebral blood flow from 1.40 ± 0.27 ml/g min~' to 0.49 ± 0.10 ml/g min...

A Model of Cerebral Blood Flow during Sustained Acceleration

Rationale: Radial accelerations generated in modern combat aircraft maneuvers (Gz) may result in impaired vision or loss of consciousness (G-LOC). We are interested in developing mathematical models of cerebral blood flow during exposure to Gz. Our previous model (1] showed that intracranial vascular resistance does not change with Gz since the vessels are protected from collapse by the cerebro...

Local cerebral blood flow following transient cerebral ischemia. I. Onset of impaired reperfusion within the first hour following global ischemia.

Using the hydrogen clearance technique, local cerebral blood flow (LCBF) in 22 dogs was estimated at 6 parietal sites prior to and following 5 min of total global ischemia. Ischemia was immediately followed by an initial reactive hyperemia during which the electrocorticogram (ECoG) usually began to recover, and within the first 30 min, most of the LCBF's decreased to subnormal values. This onse...