LncRNA MEG3 ameliorates respiratory syncytial virus infection by suppressing TLR4 signaling

Bovine respiratory syncytial virus infection.

Bovine respiratory syncytial virus (BRSV) belongs to the pneumovirus genus within the family Paramyxoviridae and is a major cause of respiratory disease in young calves. BRSV is enveloped and contains a negative sense, single-stranded RNA genome encoding 11 proteins. The virus replicates predominantly in ciliated respiratory epithelial cells but also in type II pneumocytes. It appears to cause ...

Respiratory Syncytial Virus (RSV) Infection

Breast-feeding and respiratory syncytial virus infection.

The pattern of breast-feeding in 127 infants admitted to hospital with respiratory syncytial virus infection was compared with that in 503 age-matched controls. Thirty per cent of children with infection had been breast-fed compared with 49% of controls. The approximate relative risk of being admitted to hospital with respiratory syncytial virus infection if not breast-fed was 2.2. Several othe...

Respiratory Syncytial Virus Infection In Vitro*

Background and objectives: Alveolar macrophages (AMs) are targets for respiratory syncytial virus (RSV) infection in vivo and in vitro. However, only a minority ofAMs are permissive to acute RSV infection in vitro, and it is unknown whether this permissiveness may be related to the degree of cellular maturation that is achieved in vivo. Methods: By using density gradient centrifugation, in whic...

Ribavirin for respiratory syncytial virus infection.

Over the winter of 1988, 10 infants with congenital heart disease were treated for severe bronchiolitis at Guy's Hospital. All required respiratory support of greater than 50% oxygen in a headbox, and seven required assisted ventilation. Seven patients were positive for respiratory syncytial virus, and seven received nebulised ribavirin for three to five days. There were four deaths, all infant...