LncRNA LIFR-AS1 Regulated Chemoresistance of Gastric Cancer Cells through Regulating MicroRNA-138-5p-PDK1 Axis

Cisplatin represents an important strategy for gastric cancer treatment. However, cisplatin resistance often leads to failure of therapy as well local reoccurrence. Recently, long non-coding ribonucleic acid was demonstrated exert roles in cancer. Expression measured by real time polymerase chain reaction assay cells from different groups. Cell apoptosis checked with Hoechst methods and cell counting kit-8 used determine proliferation. Bioinformatics analysis applied predict the target acid, which verified luciferase assay. We uncovered that leukemia inhibitory factor receptor antisense RNA1 significantly correlated patient survival Knockdown or overexpression resulted delayed increased proliferation lines, respectively. Moreover, response treatments, knockdown more less colony survival. Leukemia further confirmed bound micro acid-138-5p then regulates pyruvate dehydrogenase kinase 1 promote growth. Our findings provided novel mechanism targets overcoming