Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids
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چکیده
منابع مشابه
Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.
The ileal apical sodium bile acid cotransporter participates in the enterohepatic circulation of bile acids. In patients with primary bile acid malabsorption, mutations in the ileal bile acid transporter gene (Slc10a2) lead to congenital diarrhea, steatorrhea, and reduced plasma cholesterol levels. To elucidate the quantitative role of Slc10a2 in intestinal bile acid absorption, the Slc10a2 gen...
متن کاملInterruption of the enterohepatic circulation of bile acids stimulates the esterification rate of cholesterol in human liver.
The activity of acyl CoA: cholesterol acyltransferase (ACAT), which catalyzes the esterification of cholesterol, was studied in liver microsomes obtained from cholestyramine-treated gallstone patients (n = 12) and patients with Crohn's disease who had undergone partial ileal resection (n = 11). Gallstone patients (n = 33) and gallstone-free subjects undergoing cholecystectomy because of polyps ...
متن کاملThe enterohepatic circulation of bile acids during continuous liquid formula perfusion of the duodenum.
The enterohepatic circulation of bile acids was studied in 16 normal volunteers and 8 cholecystectomy patients during continuous liquid formula perfusion of the duodenum. The fasting bile acid pool size in the 16 normals (5.534 +/- 1.472 mmol) exceeded the circulating pool size (3.643 +/- 1.126 mmol) by 33.4% +/- 13.4. The difference between fasting and circulating pool sizes was significantly ...
متن کاملHepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
The bile salt export pump, encoded by ABCB11, is the predominant canalicular transport protein for biliary bile acid secretion. The level of ABCB11 expression in humans is widely variable yet the impact of this variability on human disease is not well defined. We aim to determine the effect of hepatic Abcb11 overexpression on the enterohepatic circulation (EHC) in mice. We used a stable isotope...
متن کاملOxidoreduction of different hydroxyl groups in bile acids during their enterohepatic circulation in man.
The extent of oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in bile acids during the enterohepatic circulation in man was studied with the use of [3 beta-3H]-labeled deoxycholic acid and cholic acid, [7 beta-3H]-labeled cholic acid, and [12 beta-3H]-labeled deoxycholic acid and cholic acid. Each [3H]-labeled bile acid was given per os to healthy volunteers, together with...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2018
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2018.1469685