Liver-Specific Peroxisome Proliferator-Activated Receptor Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan
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چکیده
منابع مشابه
Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan.
OBJECTIVE The angiotensin type 1 receptor blocker (ARB) and peroxisome proliferator-activated receptor (PPAR) gamma modulator telmisartan has been recently demonstrated to reduce plasma triglycerides in nondiabetic and diabetic hypertensive patients. The present study investigates the molecular mechanisms of telmisartans hypolipidemic actions, in particular its effect on the PPARalpha pathway. ...
متن کاملLiver-Specific PPARα-Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan
Objective: The angiotensin type 1 receptor blocker (ARB) and PPARγ-modulator telmisartan has been recently demonstrated to reduce plasma triglycerides in non-diabetic and diabetic hypertensive patients. The present study investigates the molecular mechanisms of telmisartans hypolipidemic actions, in particular its effect on the PPARα pathway. Research Design and Methods: Regulation of PPARα-tar...
متن کاملTelmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma.
Migration of CD4-positive lymphocytes into the vessel wall represents an important step in early atherogenesis. Telmisartan is an angiotensin type 1 receptor (AT1R) blocker with peroxisome proliferator-activated receptor (PPAR)-gamma-activating properties. The present study examined the effect of telmisartan on CD4-positive cell migration and the role of PPARgamma in this context. CD4-positive ...
متن کاملPeroxisome Proliferator-Activated Receptor Alpha Target Genes
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARα serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARα binds and is activated...
متن کاملAngiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity.
BACKGROUND Angiotensin type 1 receptor (AT(1)R) blockers (ARB) have been shown to reduce the incidence of type 2 diabetes mellitus by an unknown molecular mechanism. The peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of insulin and glucose metabolism improving insulin sensitivity. We investigated the regulation of PPARgamma function by ARBs. METHODS AND ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2008
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db07-0839