Liver progenitor cell and KDR
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منابع مشابه
Liver progenitor cell and KDR
Liver disease affects hundreds of millions of patients worldwide. Liver transplantation is currently the only curable treatment for liver failure caused by cirrhosis, chronic hepatitis B or C, bile duct disease, genetic disease, autoimmune liver disease, primary liver cancer, alcoholic liver disease, or fatty liver disease. Currently, more than 6000 liver transplants are performed each year in ...
متن کاملKDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.
Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor. hESC-derived endoderm cells do not express KDR but, when cultured in media s...
متن کاملTWEAK induces liver progenitor cell proliferation.
Progenitor ("oval") cell expansion accompanies many forms of liver injury, including alcohol toxicity and submassive parenchymal necrosis as well as experimental injury models featuring blocked hepatocyte replication. Oval cells can potentially become either hepatocytes or biliary epithelial cells and may be critical to liver regeneration, particularly when hepatocyte replication is impaired. T...
متن کاملAlcohol Disrupts Human Liver Stem/Progenitor Cell Proliferation and Differentiation
OBJECTIVE Excessive alcohol consumption injures the liver resulting in various liver diseases including liver cirrhosis. Advanced liver disease continues to be a major challenge to human health. Liver stem/progenitor cells (LSPCs) are tissue specific precursors with a distinct capacity of multi-lineage differentiation. These precursor cells may play an important role in the process of tissue in...
متن کاملA review of Biology and clinical use of Mesenchymal stem cell: an immune -modulator progenitor cell
Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.28213