Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice
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چکیده
منابع مشابه
Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice
Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mic...
متن کاملShikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway
OBJECTIVE Shikonin possesses anti-inflammatory effects. However, its function in concanavalin A-induced acute liver injury remains uncertain. The aim of the present study was to investigate the functions of shikonin and its mechanism of protection on ConA-induced acute liver injury. MATERIALS AND METHODS Balb/C mice were exposed to ConA (20 mg/kg) via tail vein injection to establish acute li...
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G protein-coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein-coupled receptors (GPCRs). The short-splice form of GIT2 is expressed in peripheral T cells and thymocytes. However, the functions of GIT2 in T cells have not yet been determined. We show that treatment with Con A in a model o...
متن کاملThe effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats
Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control...
متن کاملP45: The Effects of Nigella sativa on Sickness Behavior Induced by Lipopolysaccharide in Male Wistar Rats
Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, admin...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2015
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2015.03.007