Liver disease in transfusion dependent thalassaemia major

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Liver disease in transfusion dependent thalassaemia major.

AIMS To study the prevalence and severity of liver diseases of transfusion dependent thalassaemia major patients, and correlate the histological and biochemical changes of iron overload in liver with the peripheral blood markers. METHOD Liver biopsy was performed to assess the histological changes and liver iron content (LIC). RESULTS One hundred patients were evaluated (median age 11.7 yea...

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Chronic liver disease in transfusion-dependent thalassaemia: hepatitis B virus marker studies.

The systematic screening of 253 children with transfusion-dependent homozygous beta-thalassaemia revealed a high incidence of hepatitis B virus markers. The highest frequencies of hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) were found in the group of patients with the smallest number of transfusions, while the highest frequency of antibody to hepatiti...

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Transfusion-dependent thalassaemia: a new era.

1 Royal Australasian College of Surgeons. Surgical Education and Training program. Melbourne: RACS, 2007. http://www.surgeons.org/Content/NavigationMenu/EducationandTraining (accessed Oct 2007). 2 Royal Australasian College of Surgeons. Council highlights August 2007. Melbourne: RACS, 2007. http://www.surgeons.org/Content/NavigationMenu/WhoWeAre/Council/CouncilHighlights/Council_Highlights_Augu...

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Endocrine complications in transfusion dependent thalassaemia in Penang Hospital.

Frequent blood transfusions can lead to iron overload which may result in several endocrine complications especially in the absence of adequate chelation therapy. The objectives of this study are to determine the prevalence of endocrine complications in transfusion dependent thalassaemia patients and the correlation of endocrine complications with the degree of iron chelation. This retrospectiv...

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Spectrum of beta-thalassaemia mutations in transfusion dependent thalassaemia patients: practical implications in prenatal diagnosis.

The study concerned the identification of the beta-thalassaemia mutations that were present in 24 patients with beta-thalassaemia major who were transfusion dependent. The application of a modified polymerase chain reaction, the amplification refractory system (ARMS) was found to be an effective and rapid method for the identification of the beta-thalassaemia mutations. Six different mutations ...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2002

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.86.5.344