Liver and muscle hemojuvelin are differently glycosylated
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Muscle Liver Muscle Liver Muscle Liver Muscle Liver Muscle Liver Muscle Liver Muscle Liver Muscle Liver Muscle
We have cloned the cD)NA encoding glycogen phosphorylase (1,4-a-D-glucan:orthophosphate a-D-glucosyltransferase, EC 2.4.1.1) from human liver. Blot-hybridization analysis using a large fragment of the cDNA to probe mRNA from rabbit brain, muscle, and liver tissues shows preferential hybridization to liver RNA. Determination of the entire qucleotide sequence of the liver message has allowed a co...
متن کاملSkeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.
Hepcidin, a hormone produced mainly by the liver, has been shown to inhibit both intestinal iron absorption and iron release from macrophages. Hemojuvelin, a glycophosphatidyl inositol-linked membrane protein, acts as a bone morphogenetic protein coreceptor to activate hepcidin expression through a SMAD signaling pathway in hepatocytes. In the present study, we show in mice that loss of hemojuv...
متن کاملNa v1.4 and Na v1.5 are modulated differently during muscle immobilization and contractile phenotype conversion.
Muscle immobilization leads to modification in its fast/slow contractile phenotype. Since the properties of voltage-gated sodium channels (Na(v)) are different between "fast" and "slow" muscles, we studied the effects of immobilization on the contractile properties and the Na(v) of rat peroneus longus (PL). The distal tendon of PL was cut and fixed to the adjacent bone at neutral muscle length....
متن کاملDocosahexaenoic and eicosapentaenoic acids are differently metabolized in rat liver during mitochondria and peroxisome proliferation.
The 3-thia fatty acids, tetradecylthioacetic acid and 3,10-dithiadicarboxylic acid are mitochondrion and peroxisome proliferators. Administration of these promotes an increased transport of endogenous fatty acids to these organelles and a higher capacity of beta-oxidation. Administration of 3-thia fatty acids to rats resulted in a significant decrease of the hepatic level of docosahexaenoic aci...
متن کاملEffect of Iron Overload and Iron Deficiency on Liver Hemojuvelin Protein
INTRODUCTION Hemojuvelin (Hjv) is a key component of the signaling cascade that regulates liver hepcidin (Hamp) expression. The purpose of this study was to determine Hjv protein levels in mice and rats subjected to iron overload and iron deficiency. METHODS C57BL/6 mice were injected with iron (200 mg/kg); iron deficiency was induced by feeding of an iron-deficient diet, or by repeated phleb...
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ژورنال
عنوان ژورنال: BMC Biochemistry
سال: 2011
ISSN: 1471-2091
DOI: 10.1186/1471-2091-12-52