Liver 3-hydroxy-3-methylglutaryl-Coenzyme a reductase activity in pyridoxine-deficient rats.
نویسندگان
چکیده
منابع مشابه
Circadian variation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in swine liver and ileum.
The temporal variation of HMG-CoA reductase activity in the liver and intestine of swine was investigated. The thin-layer chromatographic method widely used in the assay of the reductase was successfully applied to the porcine enzymes. Parallel circadian rhythms were demonstrated in both hepatic and ileal reductases from mash-fed animals. Peak activity occurred approximately 6 hr after feeding,...
متن کاملPurification of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
The enzyme 3-hydroxy-3-methylglutaryl coenzyme agarose, glucose-6-phosphate dehydrogenase, and aldolA reductase from human liver was purified to homogeneity. ase were from Sigma Chemical co.; agarose-hexaneHMG-CoA was from P-L Biochemicals; bovine serum Electrophoresis of the purified human enzyme on non-denaturing gels revealed a single protein-staining band that co-migrated with reductase act...
متن کاملCytoplasmic 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase from Liver
The cytoplasmic fraction of avian liver contains multiple forms of 3-hydroxyd-methylglutaryl coenzyme A synthase which are distinct from their mitochondrial counterpart. Of the four cytoplasmic species, synthases I and II predominate, constituting 22 and 62%, respectively, of the total cytoplasmic synthase activity; synthases III and IV are minor forms comprising the remaining 16%. Each of the ...
متن کامل3-Hydroxy-3-methylglutaryl coenzyme A reductase in anencephalic and normal human fetal liver.
In previous investigations, we have found that the liver appears to be the major source of cholesterol in the human fetus, and, in particular, a principal source of circulating low density lipo-protein-cholesterol (LDL-C). LDL-C plasma levels are low in the normal fetus, most likely due to the rapid uptake and metabolism by the fetal adrenal as precursor for steroid hormone biosynthesis. In con...
متن کاملRegulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.
Addition of cholestyramine or cholestyramine plus mevinolin to the diet has been reported to increase the activity and mass of rat liver 3-hydroxy-3-methylglutaryl-CoA reductase. The present data show that these same dietary manipulations cause an induction of functional reductase mRNA. RNA was isolated from rat livers and added to an in vitro translation system, and the reductase was immunopre...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science and Vitaminology
سال: 1980
ISSN: 0301-4800,1881-7742
DOI: 10.3177/jnsv.26.1