Live tularemia vaccine confers protection against lethalLegionellaandListeriainfections in experimental animals

Synthetic peptide vaccine confers protection against murine malaria

A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoi...

Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii

The inner membrane complex (IMC) of Toxoplasma gondii as a peripheral membrane system has unique and critical roles in parasite replication, motility and invasion. Disruption of IMC sub-compartment protein produces a severe defect in T. gondii endodyogeny, the form of internal cell budding. In this study, we generated T. gondii virus-like particle particles (VLPs) containing proteins derived fr...

[The use of tularemia live vaccine in clinical oncology].

ne of the methods of the active nonspecific antitumor immunity stimulation of cancer patients is application of bacterial antigens, from which in the past BCG vaccine was the most widely adopted (1). However, this vaccine has rather variable and short-term effects (2) that need the revaccination, whereas multiple applications of the vaccine undesirably increases the activity of suppressors and ...

Identification of a Live Attenuated Vaccine Candidate for Tularemia Prophylaxis

Francisella tularensis is the causative agent of a fatal human disease, tularemia. F. tularensis was used in bioweapon programs in the past and is now classified as a category A select agent owing to its possible use in bioterror attacks. Despite over a century since its discovery, an effective vaccine is yet to be developed. In this study four transposon insertion mutants of F. tularensis live...

Aerogenic immunization of man with live Tularemia vaccine.