Liquid Biopsy in Advanced Colorectal Cancer: Clinical Applications of Different Analytes

Colorectal cancer is one of the most prevalent cancers nowadays. In metastatic setting, diagnosis and treatment have relied on tumor tissue analysis. However, different limitations this approach recently opened door to introduction liquid biopsy in clinical setting. Liquid provides real-time information about its heterogeneity a simple, non-invasive, repeatable way. There are several analytes that can be sought: exosomes, circulating cells, DNA, showing promising results areas early detection, minimal residual disease, prognosis, or response treatment. Here, we review applications advanced colorectal patients, focusing diagnosis, prognostic assessment, drug sensitivity, response, acquired resistance monitoring.