Liprin- has LAR-independent functions in R7 photoreceptor axon targeting
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چکیده
منابع مشابه
Liprin- has LAR-independent functions in R7 photoreceptor axon targeting
In the Drosophila visual system, the color-sensing photoreceptors R7 and R8 project their axons to two distinct layers in the medulla. Loss of the receptor tyrosine phosphatase LAR from R7 photoreceptors causes their axons to terminate prematurely in the R8 layer. Here we identify a null mutation in the Lipringene based on a similar R7 projection defect. Liprinphysically interacts with the inac...
متن کاملCell-Autonomous and -Nonautonomous Functions of LAR in R7 Photoreceptor Axon Targeting
During Drosophila visual system development, photoreceptors R7 and R8 project axons to targets in distinct layers of the optic lobe. We show here that the LAR receptor tyrosine phosphatase is required in the eye for correct targeting of R7 axons. In LAR mutants, R7 axons initially project to their correct target layer, but then retract to the R8 target layer. This targeting defect can be fully ...
متن کاملThe receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism.
Receptor protein tyrosine phosphatases (RPTPs) control many aspects of nervous system development. At the Drosophila neuromuscular junction (NMJ), regulation of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and on the extracellular ligands Syndecan and Dally-like. We show here that the function of LAR in controlling R7 photoreceptor axon targeting in th...
متن کاملR7 PHOTORECEPTOR AXON TARGETING AND PRESYNAPTIC ASSEMBLY IN DROSOPHILA by SCOTT HOLBROOK A DISSERTATION
Original approval signatures are on file with the Graduate School and the University of Oregon Libraries. The development of a functional nervous system is paramount for the ability of animals to interact with their environments. Minor defects in nervous system function compromise the effectiveness of sensing and responding to stimuli. Severe defects in nervous system function often lead to ext...
متن کاملThree Drosophila liprins interact to control synapse formation.
Liprin-α proteins are adaptors that interact with the receptor protein tyrosine phosphatase leukocyte common antigen-related (LAR) and other synaptic proteins to promote synaptic partner selection and active zone assembly. Liprin-β proteins bind to and share homology with Liprin-α proteins, but their functions at the synapse are unknown. The Drosophila genome encodes single Liprin-α and Liprin-...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0604766103