Lipoylating and biotinylating enzymes contain a homologous catalytic module

Lipoylating and biotinylating enzymes contain a homologous catalytic module.

Biotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl- and lipoyl-dependent enzymes is post-translationally catalyzed by specific biotinylating and lipoylating protein enzymes. In Escherichia coli, two different enzymes, LplA and LipB, catalyze ...

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

Comparison of homologous angucycline modification enzymes from five closely related Streptomyces pathways (pga, cab, jad, urd, lan) allowed us to deduce the biosynthetic steps responsible for the three alternative outcomes: gaudimycin C, dehydrorabelomycin, and 11-deoxylandomycinone. The C-12b-hydroxylated urdamycin and gaudimycin metabolites appear to be the ancestral representatives from whic...

MoNetFamily: a web server to infer homologous modules and module–module interaction networks in vertebrates

A module is a fundamental unit forming with highly connected proteins and performs a certain kind of biological functions. Modules and module-module interaction (MMI) network are essential for understanding cellular processes and functions. The MoNetFamily web server can identify the modules, homologous modules (called module family) and MMI networks across multiple species for the query protei...

Dioxygenase enzymes: catalytic mechanisms and chemical models

A relative extending module and torsion precovers

We first characterize $tau$-complemented modules with relative (pre)-covers. We also introduce an extending module relative to $tau$-pure submodules on a hereditary torsion theory $tau$ and give its relationship with $tau$-complemented modules.