Lipopolysaccharide enhances CD11b/CD18 function but inhibits neutrophil aggregation

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Lipopolysaccharide enhances CD11b/CD18 function but inhibits neutrophil aggregation.

Human neutrophils are primed in the presence of complexes of lipopolysaccharide (LPS) with its serum binding protein (LBP) in a manner dependent on CD14. Cellular consequences of priming include increased responsiveness, the upregulation of surface proteins including the adhesive integrin CD11b/CD18 (Mac-1), the increased binding of certain ligands to CD11b/CD18, and the concurrent shedding of ...

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ژورنال

عنوان ژورنال: Blood

سال: 1994

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v83.11.3303.3303