Lipoic acid pharmacokinetics at baseline and 1 year in secondary progressive MS
نویسندگان
چکیده
منابع مشابه
Lipoic Acid Pharmacokinetics at Baseline and 1 year in Secondary Progressive MS
Lipoic acid (LA) is a waterand fat-soluble oral antioxidant with anti-inflammatory properties. It has demonstrated benefits in animal models of MS and has been evaluated for MS relapse prevention and neuroprotection. However, there are relatively a few data regarding LA pharmacokinetics (PK) in elderly populations or with use beyond 4 days. In addition, studies have used a variety of doses, a w...
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Objective: To determine whether lipoic acid (LA), an endogenously produced antioxidant, slowed the whole-brain atrophy rate and was safe in secondary progressive MS (SPMS). Methods: Patients with SPMS aged 40–70 years enrolled in a single center, 2-year, double-blind, randomized trial of daily oral 1,200mg LA vs placebo. Primary outcomewas change in annualized percent change brain volume (PCBV)...
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α-Lipoic acid (LA) is widely used for nutritional supplements as a racemic mixture, even though the R enantiomer is biologically active. After oral administration of the racemic mixture (R-α-lipoic acid (RLA) and S-α-lipoic acid (SLA) mixed at the ratio of 50:50) to rats, RLA showed higher plasma concentration than SLA, and its area under the plasma concentration-time curve from time zero to th...
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Rosmarinic acid (RA), one of the main bioactive compounds of Rosmarinus officinalis L., exhibits diverse pharmacological effects. However, its oral absolute bioavailability and dose proportionality in vivo have not been comprehensively studied. In the present study, a validated LC-MS/MS method was developed for the determination of RA in rat plasma. Pharmacokinetic parameters were obtained foll...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2017
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000380