Lipofuscin: formation, effects and role of macroautophagy
نویسندگان
چکیده
منابع مشابه
Lipofuscin: formation, effects and role of macroautophagy☆
Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin. These aggregates of damaged proteins are detrimental to n...
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Mitochondrial contribution to lipofuscin formation
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production of ROS during the oxidative phosphorylation. The hypothesis exists that mitochondria are involved in the formation of lipofuscin, an autofluorescent protein aggregate that accumulates progressively over time in lysosomes of post-mitotic and senescent cells. To investigate the...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2013
ISSN: 2213-2317
DOI: 10.1016/j.redox.2013.01.006