Lipoblastoma-like tumor of the vulva: A rare benign mesenchymal neoplasm mimicking myxoid liposarcoma

Abstract Introduction/Objective Lipoblastoma-like tumor of the vulva (LLTV) is a rare, benign mesenchymal neoplasm adipocytic differentiation that typically presents as vulvar mass in young women, clinically mimicking Bartholin gland abnormality. The well-circumscribed and multilobulated, composed mature adipocytes, uniloculated lipoblasts bland spindle cells. Morphologic features often overlap with lipoblastoma, myxoid liposarcoma, cell lipoma; however, absent alterations PLAG1 HMGA2 distinguish it from lack DDIT3 gene rearrangement distinguishes liposarcoma. While Rb1 usually demonstrates “mosaic” pattern expression, no definitive evidence structural abnormality 13q has been identified. Methods/Case Report A 24-year-old female presented mild discomfort persistent swelling right for one year, which was initially thought to be cyst. Physical examination revealed marked asymmetry between left vulva, ultrasound an ovoid, hypoechoic, solid- appearing (4.7 x 2.5 1.1 cm). She subsequently underwent excision diagnosis treatment. Results (if Case Study enter NA) specimen showed relatively multi-lobulated subcutaneous stroma thin fibrous septa. mixture cells, adipocytes. No significant nuclear atypia, necrosis or mitotic activity Immunohistochemical stains cells were negative keratin cocktail, S100 protein, SMA, Desmin. CD34 highlighted vessels within lesion, "mosaic" weak expression. Conclusion tends occur Recognition this rare entity distinction mimics including liposarcoma essential avoid overly aggressive Complete conservative recommended.