Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles

Spray-congealing, a technique based on the fast solidification of sprayed molten lipids, is considered novel strategy to encapsulate natural products. Among others, it safe, low cost, and reproducible technique, with rising interest for several applications (e.g. food applications). One key parameters application this lipid temperature, which can be modulated by optimizing composition. In work, three components (beeswax, carnauba wax, medium-chain triglycerides (Miglyol 812)) were selected, mixture composition modelled using simplex-centroid experimental design. Three different compositions chosen validate proposed model, then tested in preparation curcumin-loaded microparticles (1.5%, w/w). The produced analysed terms colour, morphology, particle size, encapsulation efficiency load, physicochemical, crystalline, thermal properties. Results evidenced that microparticle’s properties, including efficiency, vary according used mixture, supporting their tailoring role. This fact brings advantages design microencapsulation systems spray congealing processes, broadening applicability. Moreover, optimisation was proved an important tool precede development spray-congealing applications.