Lipid complexing decreases amphotericin B inflammatory activation of human neutrophils compared with that of a desoxycholate-suspended preparation of amphotericin B (Fungizone)
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چکیده
منابع مشابه
Lipid complexing decreases amphotericin B inflammatory activation of human neutrophils compared with that of a desoxycholate-suspended preparation of amphotericin B (Fungizone).
Amphotericin B (AmB) has toxic effects and alters neutrophil (polymorphonuclear leukocyte [PMN]) function. A lipid-complexed formulation of AmB (AmB-LC) has been reported (A. S. Janoff, L. T. Boni, M. C. Popescu, S. R. Minchey, P. R. Cullis, T. D. Madden, T. Taraschi, S. M. Gruner, E. Shyamsunder, M. W. Tate, R. Mendelsohn, and D. Bonner, Proc. Natl. Acad. Sci. USA 85:6122-6126, 1988) to be les...
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Correspondence Nephrotoxicity of Amphotericin B Desoxycholate Sir—We read with great interest the study of Bates et al. [1], which assessed the mortality and financial cost of acute renal failure associated with use of am-photericin B desoxycholate at a single ter-tiary-care hospital. Among 707 adults admitted to the hospital and given parenteral amphotericin B therapy, 30% had acute renal fail...
متن کاملLipid membrane-binding properties of amphotericin B deoxycholate (Fungizone) using surface plasmon resonance.
In the present study, we developed an assay of interactions of amphotericin B (AmB) deoxycholate, Fungizone, with two model lipid membranes that mimicked mammal cell membranes and fungal membranes. We also analyzed the binding kinetics of the mammal cell membranes and fungal membranes using surface plasmon resonance (SPR). Fungizone showed a higher affinity for the model fungal membrane than th...
متن کاملControlled trials of amphotericin B lipid complex.
because it occurred in the midst of the usual seasonal increase in the number of cases of enteroviral meningitis together with cases of herpes simplex virus 1 (HSV-1) encephalitis, which occurs sporadically throughout the year. HSV-1 encephalitis may be differentiated from WNE by the presence of focal abnormalities on the electroencephalogram and/or on CT/MRI scans. Most cases of enteroviral me...
متن کاملComparative efficacies of amphotericin B lipid complex and amphotericin B deoxycholate suspension against murine blastomycosis.
Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001). Fungizone was more effective than lipid complex at doses of 0.8 mg/kg of body weight. However, lipid complex at 12.8 mg/kg was not toxic and superior in efficacy (P less than 0.001) to 2.0 mg of Fungizone p...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1992
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.36.1.39