Lipid-Based Drug Delivery System (LBDDS): An Emerging Paradigm to Enhance Oral Bioavailability of Poorly Soluble Drugs

Low-oral bioavailability as a consequence of low-water solubility drugs is challenging for formulation scientists in the development new pharmaceutical products. This review aims to highlight relevant considerations when implementing rational strategy lipid-based oral drug delivery systems and discuss shortcomings challenges current classification these such nanoemulsion, Solid lipid nanoparticle (SLN), Nanostructured carriers (NLC), Self-emulsifying system (SEDDS). Lipid-based consist diverse group formulations, each consisting varying functional structural properties that are amenable modifications achieved by composition excipients other additives thereby facilitating poorly water-soluble drugs. In addition, nanoparticles may also protect loaded from chemical enzymatic degradation gradually release molecules matrix into blood, resulting improved therapeutic profiles compared free Therefore, due their physiological biodegradable properties, decrease adverse side effects chronic toxicity drug-delivery others polymeric nature. Accordingly, present mainly centred on various used (LBDDS).