منابع مشابه
Links Between Repeated Sequences
L1 and Alu elements are long and short interspersed retrotransposable elements (LINEs and SINEs) in humans, respectively. Proteins encoded in the autonomous L1 mediate retrotransposition of the nonautonomous Alu and cellular mRNAs. Alu is the only active SINE in the human genome and is derived from 7SL RNA of signal recognition particle. In the other eukaryotic genomes, various tRNA- and 5S rRN...
متن کاملAnalysis in Bacteria: Recombination Between Repeated, Inverseorder Chromosomal Sequences
In standard bacterial recombination assays, a linear fragment of DNA is transferred to a recipient cell and, at most, a single selected recombinant type is recovered from each merozygote. This contrasts with fungal systems, for which tetrads allow recovery of all meiotic products, including both ultimate recombinant products of an apparent single act of recombination. We have developed a bacter...
متن کاملChromosome rearrangements via template switching between diverged repeated sequences.
Recent high-resolution genome analyses of cancer and other diseases have revealed the occurrence of microhomology-mediated chromosome rearrangements and copy number changes. Although some of these rearrangements appear to involve nonhomologous end-joining, many must have involved mechanisms requiring new DNA synthesis. Models such as microhomology-mediated break-induced replication (MM-BIR) hav...
متن کاملCis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.
In mammalian cells, little is known about the nature of recombination-prone regions of the genome. Previously, we reported that the immunoglobulin heavy chain (IgH) mu locus behaved as a hotspot for mitotic, intrachromosomal gene conversion (GC) between repeated mu constant (Cmu) regions in mouse hybridoma cells. To investigate whether elements within the mu gene regulatory region were required...
متن کاملDegree Sequences with Repeated Values
A given nonincreasing sequence D = (d1, d2, · · · , dn) is said to contain a (nonincreasing) repetition sequence D∗ = (di1 , di2 , · · · , dik ) for some k ≤ n − 2 if all values of D −D∗ are distinct and for any dil ∈ D ∗ there exists some dt ∈ D −D∗ such that dil = dt. For any pair of integers n and k with n ≥ k + 2, we investigate the existence of a graphic sequence which contains a given rep...
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ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2006
ISSN: 1110-7243
DOI: 10.1155/jbb/2006/13569